Research > Microbe > Viruses > sars-cov-2 (covid-19)

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Research

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Common Generic Names

Electrolytically Generated Hypochlorous Acid (HOCl)
Neutral Electrolyzed Water (NEW)
Electrolyzed Oxidizing Water (EOW)
Electro-chemically Activated Water (ECA)
Super-oxidized water (SOW)

Results: 8 published articles

Microbe(s): influenza, coronavirus, SARS-CoV-2, COVID-19

ABSTRACT – Full Text PDF

Slightly acidic hypochlorous acid waters (SAHWs) with pH of 5.25.8 containing different concentrations of free available chlorine – 62, 119, 220, 300, and 540 ppm (SAHW-62, -119, -220, -300, and -540, respectively) – were evaluated for their virucidal activity toward a low pathogenic H7N1 avian influenza virus (AIV) and an infectious bronchitis virus (IBV) in suspension, abiotic carrier, and direct spray tests, with the presence of organic materials. In the carrier test, the plastic carriers, while viruses remained in the wipes. Besides, a small volume of sprayed SAHW was effective against the viruses on the rayon sheets for daily cleaning in the application area. The findings we obtained concerning IBV might basically be applicable in relation to SARS-CoV-2, given the resemblance between the two viruses.

Microbe(s): COVID-19, Coronavirus, SARS-CoV-2

ABSTRACT – Full Text PDF

This work is part of a project on the development of a smart prefabricated sanitising chamber (SPSC) to provide extra measures against the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Stabilised hypochlorous acid (HOCl) is an approved disinfectant against SARS-CoV-2 by the Environmental Protection Association US in its liquid form on non-porous surfaces. This review is extended to cover its viricidal/bactericidal efficacy in aerosolised or sprayed form which showed an effective dose of as low as 20 ppm and the exposure duration of at least 60 s. The aerosolised application was also recommended with particle size of less than 200 m to increase the contact with pathogens. The review also includes the safety and toxicity of HOCl with different concentrations. The review calls for more investigations into the effect of HOCl in mist and fog form on the respiratory system when transitioning through the proposed SPSC.

Microbe(s): COVID-19, Coronavirus, SARS-CoV-2

ABSTRACT – Full Text PDF

To eliminate the COVID-19 pandemic, the transmission of the virus SARS-CoV-2 among the population needs to be blocked and/or at least reduced. Upper respiratory tract viral loads are highest in the early stages of the disease, and high loads are associated with higher mortality rates. This study aims to evaluate the virucidal efficacy of AOS2020, a novel sprayable Acid-Oxidizing solution containing pure and stable hypochlorous acid (HClO), on human coronavirus SARS-Cov-2 in vitro, and the tolerability profile on nasal and oral mucosa suggesting to be a potential solution for upper respiratory hygiene. Virucidal assays and intranasal and oral irritation tests were undertaken in accordance with relevant national and international guidance and methods. In pre-clinical tests, the AOS2020, showed>99.8 virucidal efficacy in<1 min against SARS-Cov-2. The safety profile testing on both the nasal and oral mucosa indicates that AOS2020 is non-irritant. These initial results indicate that this product has the potential treatment to reduce viral in the upper respiratory tract.

Microbe(s): COVID-19, Coronavirus, SARS-CoV-2

ABSTRACT – Full Text PDF

Infectious SARS-CoV-2 can be recovered from the oral cavities and saliva of COVID-19 patients with potential implications for disease transmission. Reducing viral in patient saliva using antiviral mouthwashes may therefore have a role as a control measure in limiting virus spread, particularly in dental settings. Here, the efficacy of SARS-CoV-2 inactivation by seven commercially available mouthwashes with a range of active ingredients were evaluated in vitro. We demonstrate 4.1to 5.5 log10 reduction in SARS-CoV-2 titre following a 1min treatment with commercially available mouthwashes containing 0.010.02% stabilised hypochlorous acid or 0.58% povidone iodine, and non-specialist mouthwashes with both alcohol-based and alcohol-free formulations designed for home use. In contrast, products containing 1.5% hydrogen peroxide or 0.2% chlorhexidine gluconate were ineffective against SARS-CoV-2 in these tests. This study contributes to the growing body of evidence surrounding virucidal efficacy of mouthwashes/oral rinses against SARS-CoV-2, and has important applications in reducing risk associated with aerosol generating procedures in dentistry and potentially for infection control more widely.

Microbe(s): COVID-19, Coronavirus, SARS-CoV-2

ABSTRACT – Full Text PDF

SARS COVID-19 is a potentially lethal viral infection transmitted from the mouth, nose and eyes of infected patients. Ophthalmologists have died of this disease. For eye care specialists, the new normal includes asking our patients to wear a mask, gloves and to stay at least 6 feet away. The latter being impossible during an eye examination. The mask acts as a barrier to respiratory virion touching the patient eyes, eye lid skin and tears.

Microbe(s): SARS-CoV-2, COVID 19

ABSTRACT – Full Text PDF

EcoloxTech systems were used to generate a 130 ppm electrolyzed water solution of hypochlorous acid. A greater than 4-log reduction or complete kill was obtained on all 3 replicates studied after a 5 minute contact time. This test was performed in order to substantiate virucidal efficacy claims for a test substance to be labeled as a virucide by determining the potential of the test substance to disinfect hard surfaces contaminated with Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) (COVID-19 Virus). This test was designed to simulate consumer and was performed in conformance to EPA OCSPP 810.2000 (2018) and 810.2200 (2018) Product Performance Test Guidelines.

Microbe(s): COVID-19, SARS-CoV-2, Coronavirus

ABSTRACT – Full Text PDF

The surgeon needs to have an inexpensive, available, nontoxic, and practical disinfectant that is effective in sanitizing against the COVID-19 (Coronavirus Disease 2019) virus. The purpose of this article was to review the evidence for using hypochlorous acid in the office setting on a daily basis. The method used to assemble recommendations was a review of the literature including evidence for this solution when used in different locations and industries other than the oral-maxillofacial clinic facility. The results indicate that this material can be used with a high predictability for disinfecting against the COVID-19 (Coronavirus Disease 2019) virus.

Microbe(s): SARS-CoV-2, COVID 19

ABSTRACT – Full Text PDF

EcoloxTech systems were used to generate a 130 ppm electrolyzed water solution of hypochlorous acid. A greater than 4-log reduction or complete kill was obtained on all 3 replicates studied after a 5 minute contact time. This test was performed in order to substantiate virucidal efficacy claims for a test substance to be labeled as a virucide by determining the potential of the test substance to disinfect hard surfaces contaminated with Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) (COVID-19 Virus). This test was designed to simulate consumer and was performed in conformance to EPA OCSPP 810.2000 (2018) and 810.2200 (2018) Product Performance Test Guidelines.

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